Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

By Leanne Wilson-Fritch, S. Nicoloro, My Chouinard, Mitchell A. Lazar, Patricia C. Chui, J. Leszyk, J. Straubhaar, M. Czech, S. Corvera. Journal of Clinical Investigation, 2004

610 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/813866cb631be35d7fe0765526411a0a4cacdc02

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Citations in the corpus

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. (2006, background): “Rosiglitazone treatment of obese mice boosts PGC-1 transcription in WAT concomitant with increased mitochondrial function and, more importantly, insulin sensitivity (76).”
Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “Brown in white (brite) cells The effects of thiazolidinediones (TZDs) and other PPARg agonists on mitochondrial biogenesis and respiration in WATs have been well documented (Fukui et al. 2000; Laplante et al. 2003; Wilson-Fritch et al. 2003, 2004; Vernochet et al. 2009).”
PPAR agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein (2012, positive): “Anti-diabetic PPARγ ligand drugs, such as rosiglitazone, have been shown to have the ability to turn on a thermogenic gene program in brown fat and activate a “browning” of white adipose tissues (Fukui et al., 2000; Petrovic et al., 2009; Rong et al., 2007; Sell et al., 2004; Tai et al., 1996; Verno”
The many faces of PPARgamma. (2005, positive): “In addition, TZDs induce the coactivator PPARγ-coactivator 1a (PGC-1α), which promotes mitochondrial biogenesis (Wilson-Fritch et al., 2004), leading to an increase in fatty-acid oxidation that further protects against adipocyte hypertrophy.”
PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “Moreover, the genes encoding mitochondrial proteins reduce in obese mice without diabetes, which are upregulated after rosiglitazone treatment [165].”
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling (2011, background): “Finally, we also observed elevated protein expression of multiple essential mitochondrial gene products (Wilson-Fritch et al., 2004), ATP synthase, and cytochrome oxidase in 3T3-L1 cells expressing shSmad3 lentivirus and in Smad3 / WAT (Figures S2B and S2C).”