Intrinsic disorder in cell-signaling and cancer-associated proteins.
By Lilia M. Iakoucheva, C. Brown, J. David Lawson, Zoran Obradovic, A. Keith Dunker. Journal of Molecular Biology, 2002
1,187 citations recorded by the source corpus.
Subfields: Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/81371bea6610312e8804ecdf1767ef8684e2b3a4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Materials Chemistry
- Vladimir N Uversky
- A. Keith Dunker
- Lukasz Kurgan
- Zsuzsanna Dosztányi
- Burkhard Rost
- Avner Schlessinger
- Christopher J. Oldfield
- Bálint Mészáros
In Molecular Biology
- Vladimir N Uversky
- Lukasz Kurgan
- A. Keith Dunker
- Zsuzsanna Dosztányi
- Burkhard Rost
- Zhenling Peng
- Christopher J. Oldfield
- Avner Schlessinger
Citations in the corpus
- Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. (2004, background): “Native disorder has been implicated in cancerassociated proteins present in the human genome.(22) Figure 5 provides further detail on the causal mechanisms of cancer that may involve disorder such as gene silencing, epigenetic regulation of expression(25) and DNA repair.”
- Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling (2005, background): “…below for reasons for choosing this term) carry out numerous important biological functions and their structural plasticity has been shown to have significant functional implications (Uversky et al., 2000; Dunker and Obradovic, 2001; Dunker et al., 2002a; Iakoucheva et al., 2002; Uversky, 2002a).”
- Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics (2019, background): “Intrinsic disorder forms the basis of the dynamic “on-off” switch-type interactions commonly found in signaling networks, where IDPs/IDPRs bind partners with low affinity and high specificity [4, 140, 141].”
- Flexible nets (2005, background): “Furthermore, these intrinsically disordered (ID) proteins and regions are known to carry out numerous biological functions including cell signaling [35], molecular recognition [48], and various other interactions with proteins and nucleic acids [32,34,35,37,39–43,49 Recently, a number of groups…”
- Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly (2017, background): “It is notable that components of all of these assemblies are enriched in IDRs (Banani et al., 2016; Hegde et al., 2010; Hnisz et al., 2017; Iakoucheva et al., 2002; Kai, 2016; Minezaki et al., 2006).”
- Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners (2008, result): “Both predictors give good agreement with the experimental determination of intrinsic disorder [83,91-109], and in the case of p53 both of their predictions agree well with experimental characterization.”
- Identification, Analysis and Prediction of Protein Ubiquitination Sites (2010, background): “This graph shows the composition of these three datasets relative to the composition of completely ordered proteins from PDB-Select-25.”
- Composition Profiler: a tool for discovery and visualization of amino acid composition differences (2007, background): “It has since been used in studies of cell-signalling and cancer-associated proteins [20], serine/arginine-rich splicing factors [21] and hub proteins of PPI networks [18], among others.”