Refined structure of the nicotinic acetylcholine receptor at 4A resolution.

By N. Unwin. Journal of Molecular Biology, 2005

1,717 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/807b0525654c72a48b3f5500c6aaf5136cd561c7

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Citations in the corpus

MOLE 2.0: advanced approach for analysis of biomacromolecular channels (2013, background): “The central pore (Figure 7D) of the nicotinic acetycholine receptor (2BG9) was suggested to be lined by 18 negatively charged amino acids, which explains the experimentally observed selectivity for cation permeation [52].”
RCSB Protein Data Bank: Enabling biomedical research and drug discovery (2019, background): “59 A large collection of toxins, poisons, and drugs act through these pentameric receptors, including the two well-known poisons curare and strychnine 60 ; anesthetics and alcohol 61 ; benzodiazopine anti-depressants 62 ; and the antiparasitic agent ivermectin.”
Structure-based drug discovery and protein targets in the CNS. (2011, background): “Electron crystallography of the receptor isolated from the fish electric organ (Unwin, 2005) resulted in a structure refined to 4 Å resolution.”
GABAA Receptors: Subtypes Provide Diversity of Function and Pharmacology (2008, neutral): “This conclusion is also consistent with homology modeling using Unwin (2005) structure of the nAChR as a template.”
Membrane curvature and mechanisms of dynamic cell membrane remodelling (2005, background): “This shape is seen for the transmembrane domain of the nicotinic acetylcholine receptor, which has been observed at the tops of membrane folds at the neuromuscular junctio”
Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function (2009, methodology): “More recently, these methods have been complemented and extended by advancements in defining receptor structure at atomic resolution through the high-resolution electron microscopy visualization of the Torpedo receptor by the Unwin group (476) and X-ray studies of the crystallized AChBP from mollusk”
International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “The complete channel structure has been progressively well resolved (currently 4 Å) for the nAChR of Torpedo mar-morata obtained by cryoelectron microscopy and image reconstruction (Miyazawa et al., 2003, Unwin, 2005).”
DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy. (2009, background): “Theoretical calculations (Henderson 1995; Glaeser 2004), as well as practical experience (Unwin 2005; Yu et al. 2008; Zhang et al. 2008), indicate that over one million asymmetric subunits are required to achieve resolutions high enough to trace the backbone of macromolecular complexes.”