Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System

By S. Riethdorf, H. Fritsche, V. Müller, T. Rau, C. Schindlbeck, B. Rack, W. Janni, C. Coith, K. Beck, F. Jänicke and 4 more. Clinical Cancer Research, 2007

1,269 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/8065faabab68dd4cff1c2e26f8f15f6f0449a668

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. L. Terstappen
2. K. Pantel
3. G. Doyle
4. M. Miller
5. Ruud H. Brakenhoff
6. B. Brandt
7. C. Alix‐Panabières

In Oncology

1. K. Pantel
2. G. Doyle
3. L. Terstappen
4. M. Miller
5. Ruud H. Brakenhoff
6. B. Brandt
7. C. Alix‐Panabières
8. J. Massagué

Citations in the corpus

• Circulating Tumor Cells Predict Survival in Early Average-to-High Risk Breast Cancer Patients (2014, methodology): “Nevertheless, the CellSearch system has shown highly reproducible and automated detection of CTCs in interlab validation trials (34,35).”
• Detection, clinical relevance and specific biological properties of disseminating tumour cells (2008, methodology): “Crucial steps in the procedure are the sampling techniques and the methods used, including the antibodie”
• Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. (2012, methodology): “CTC Analysis CTC analysis was performed using CellSearch, as previously described.(10,11) CTCs were defined as cells coexpressing EpCam and cytokeratins (8, 18, and 19) without expression of the WBC surface marker CD45 and had a 4 ,6-diamidino-2-phenylindole (DAPI) –stained nucleus.”
• Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer (2009, methodology): “The CellSearch Circulating Tumor Cell System has been validated via a rigorous clinical testing program [9–18] and is the only FDA cleared device for the enumeration of CTC in whole blood.”
• Circulating tumor cells: approaches to isolation and characterization (2011, neutral): “The CellSearch system (Veridex), a widely used FDA (Food and Drug Administration)–approved method, uses ferrofluids loaded with an EpCAM antibody to capture CTCs, which are subsequently visualized by staining with a cocktail of antibodies against the cytoplasmic epithelial cytokeratins (8, 18, and 1”