Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues
By Rahul K. Das, Rohit V. Pappu. Proceedings of the National Academy of Sciences of the United States of America, 2013
939 citations recorded by the source corpus.
Subfields: Food Science, Mathematical Physics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8050e5cd53af5cbcd986f78c1895475f84bb64b6
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In Food Science
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- Zsuzsanna Dosztányi
- Vladimir N Uversky
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- Lukasz Kurgan
- Robert D. Finn
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Citations in the corpus
- Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins (2016, background): “Dimensions of individual IDP molecules are affected not only by their total charges [51] but also sequence arrangement of charges [52]; their response to denaturant is different from that of unfolded globular proteins [53].”
- InterPro in 2019: improving coverage, classification and access to protein sequence annotations (2018, background): “For example, it has been shown that strong polyampholytes have a preference for random coil or more compact conformations, depending on charge segregation (37).”
- MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins (2017, background): “It distinguishes different types of disordered regions by measuring the fraction of charged residues and net charge according to a previous classification (55).”
- Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics (2019, methodology): “In other words, the fractions of both positive (f) and negative charges (f) can be used for conformational classification IDPs, generating a specific diagram-of-states [68, 71] and can even be used for gaining some knowledge on the IDP functionality [72].”
- Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization (2015, neutral): “As with generic IDPs (Das and Pappu, 2013; Das et al., 2015; MüllerSpäth et al., 2010), amino acid composition and sequence patterning likely determine interactions within and conformational properties of LCDs and encode their ability to undergo phase separation.”