Epigenetics in Human Obesity and Type 2 Diabetes
By C. Ling, T. Rönn. Cell Metabolism, 2019
768 citations recorded by the source corpus.
Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, and RNA-mediated processes, and disruption of this balance may cause several pathologies and contribute to obesity and type 2 diabetes (T2D). This Review summarizes epigenetic signatures obtained from human tissues of relevance for metabolism—i.e., adipose tissue, skeletal muscle, pancreatic islets, liver, and blood—in relation to obesity and T2D. Although this research field is still young, these comprehensive data support not only a role for epigenetics in disease development, but also epigenetic alterations as a response to disease. Genetic predisposition, as well as aging, contribute to epigenetic variability, and several environmental factors, including exercise and diet, further interact with the human epigenome. The reversible nature of epigenetic modifications holds promise for future therapeutic strategies in obesity and T2D.
Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health, Surgery
View Paper: https://www.semanticscholar.org/paper/804bf10024625df172a07ec0c5c44d2249f1816a
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Citations in the corpus
- Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “Epigenetic dysregulation in IR Recent studies have suggested that epigenetic modifications such as DNA methylation (DNAm) and histone post-translational modifications (PTM) are implicated in the development of systemic IR.(200,201)”