Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy

By Casper Paludan, D. Schmid, Markus Landthaler, M. Vockerodt, D. Kube, Thomas Tuschl, C. Münz. Science, 2005

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “Chloroquine suppresses the immunological response in a manner that is not due to its pH-dependent lysosomotropic accumulation (chloroquine interferes with lipopolysaccharideinduced Tnf/Tnf-a gene expression by a nonlysosmotropic mechanism),(998) as well as through its pH-dependent inhibition of anti”
Eaten alive: a history of macroautophagy (2010, background): “In particular, Munz's laboratory provided the first demonstration that autophagy is involved in efficient MHC class II presentation of an endogenously synthesized viral protein (Epstein-Barr virus nuclear antigen 1; EBNA1”
Autophagy in immunity and inflammation (2011, background): “Autophagy proteins may participate in different facets of antigen presentation, including the delivery of endogenous antigens for MHC class II presentation to CD4 + T cells 74, 75 , the enhancement of antigen donor cell cross-presentation to CD8 + T cells 75 , dendritic cell crosspresentation of pha”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “Chloroquine suppresses the immunological response in a manner that is not due to its pHdependent lysosomotropic accumulation (chloroquine interferes with lipopolysaccharide-induced TNF-a gene expression by a nonlysosmotropic mechanism),(651) as well as through its pHdependent inhibition of antigen p”