Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.

By Jeremy S. Duffield, S. Forbes, C. Constandinou, S. Clay, M. Partolina, Srilatha Vuthoori, Shengjia Wu, R. Lang, J. Iredale. Journal of Clinical Investigation, 2005

1,656 citations recorded by the source corpus.

Subfields: Hepatology, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/7ffc8f6e169f416274c6cc88e9bbb4c93a4978f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. F. Tacke
2. TA Wynn
3. Natascha Roehlen
4. E. Crouchet
5. T. Baumert
6. A. Ramachandran
7. Robert F. Schwabe
8. E. Seki

In Immunology

1. TA Wynn
2. J. Pollard
3. J. Joyce
4. P. Murray
5. Binzhi Qian
6. F. Tacke
7. Jiu-feng Li
8. Yan Deng

In Surgery

1. TA Wynn
2. A. Ramachandran
3. M. Krenz
4. P. Scherer
5. H. Jaeschke
6. P. Murray
7. F. Tacke
8. A. Goldfine

Citations in the corpus

• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “2000) and for recovery from inflammatory liver injury and scarring (Duffield et al. 2005; Fallowfield et al. 2007).”
• TLR4 enhances TGF-β signaling and hepatic fibrosis (2007, background): “, in the liver, where they have a crucial role in hepatic fibrogenesis by enhancing HSC activatio”
• Fat Treg cells: a liaison between the immune and metabolic systems (2009, background): “, prompting widespread use of this approach to probe diverse immunological issues through specific ablation of particular cell types, including T reg cell”
• Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. (2010, methodology): “Quantitative morphometry was performed as previously reported.(41) Tubule injury was assessed by a semiquantitative scoring system as previously described.”
• Macrophage heterogeneity in liver injury and fibrosis. (2014, background): “In congruence with the fact that liver fibrosis is not an unidirectional irreversible process, hepatic macrophages can actually exert dual functions in the context of experimental liver fibrosis by either promoting or abrogating the excessive deposition of extracellular matrix [2].”
• Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications (2007, background): “ATM s are likely to be important mediators of these AT remodeling functions as well (18,19,21).”
• Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “In contrast, macrophage depletion during recovery leads to a failure of ECM degradation and a less efficient repair [81].”
• A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth (2009, methodology): “expression of the diptheria toxin receptor from the CD11b promoter [35].”