Evidence that cytokines play a role in rheumatoid arthritis.

By F. Brennan, I. McInnes. Journal of Clinical Investigation, 2008

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Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis (2010, background): “Other newly described cytokines implicated in RA, the IL-1 family members IL-18 and IL-33 and the novel cytokine IL-32, can also be produced by cytokine stimulated FLS (109).”
Mechanisms of inflammation-driven bacterial dysbiosis in the gut (2016, positive): “Dampening inflammation would be an ideal approach to restricting blooms of Enterobacterieaceae as well as many detrimental effects of inflammation, but it remains a challenge to tone down inflammatory response, as seen in the treatment for rheumatoid arthritis and cancer.(111,112) Thus, maneuvering ”
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis (2020, background): “Especially TNF-α, which is also produced by synovial macrophages, B-, and NK-cells is one of the most important mediators of joint inflammation in RA [60].”