GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.

By H. Kouros-Mehr, E. Slorach, M. Sternlicht, Zena Werb. Cell, 2006

695 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/7feb6affdaba3592f2569806c36dd62cb74ee521

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In Molecular Biology

In Oncology

In Pulmonary and Respiratory Medicine

Citations in the corpus

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors (2007, background): “Taken together, these data suggest that the human 'luminal' profile may actually be a combination of at least two profiles, one of which is ER-regulated and another of which is GATA3-regulated; support for a link between GATA3 and luminal cell origins comes from GATA3 loss studies in mice where the ”
Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery (2009, background): “1H, and not shown) [24–27], as well as genes associated with luminal epithelial differentiation (e.g. GATA3 and FOXA1, Fig.”
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. (2008, neutral): “FoxA1 (Hepatocyte Nuclear Factor 3a), a member of the Forkhead family of winged-helix transcription factors, is involved in the development and differentiation of several organs including liver, kidney, pancreas, lung, prostate, and mammary gland (Friedman and Kaestner, 2006; Kouros-Mehr et al., 20”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “2007) and maintains cellular differentiation in the adult (Kouros-Mehr et al. 2006).”
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs (2011, background): “Moreover, the mammary differentiation marker GATA3 (ref”
The emerging roles of forkhead box (Fox) proteins in cancer (2007, background): “Breast cancer arises from the luminal epithelium, and maintenance of luminal epithelial cell differentiation requires the zinc-finger transcription factor GATA3 (Ref”
Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy (2011, background): “For example, GATA3 is required for luminal differentiation in the breas”