FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

By M. Lupien, J. Eeckhoute, Clifford A. Meyer, Qianben Wang, Yong Zhang, Jason S. Carroll, X. S. Liu, Myles A. Brown. Cell, 2008

987 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bc7171cb905c39c4db07049d9fea784292dedac8

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Citations in the corpus

Model-based Analysis of ChIP-Seq (MACS) (2008, methodology): “ChIP-chip data for FoxA1 and controls in MCF7 cells were previously published [1], and their corresponding ChIP-Seq data were generated specifically for this study.”
Enhancer function: new insights into the regulation of tissue-specific gene expression (2011, neutral): “, FOXA1-regulated genes in MCF7 breast cancer cells and LNCaP prostate cancer cell”
An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression (2010, background): “The next strongest overlap was of AR with FoxA1and Ace-H3, both of which have been previously reported (Jia et al., 2008; Lupien et al., 2008).”
Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes (2009, background): “, 2004), and whose related family member, HNF3 (FOXA1), serves as a “pioneer factor” that binds to nucleosomal DNA at distant enhancers and facilitates recruitment of other tissue-specific factors (Lupien et al., 2008).”
Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer (2009, background): “Consistent with our recent finding that KDM1 over-expression reduces FoxA1 recruitment in MCF7 cells (Lupien et al., 2008), we found that KDM1 over-expression decreases FoxA1 binding and H3K4me2 level at the UBE2C enhancers (Figure S8).”
Discovery and characterization of chromatin states for systematic annotation of the human genome (2010, background): “First, we found that the descriptive power of the model was appropriately spent, allocating more states to capture biologically-meaningful complexity in small regions, for example dedicating 11 states (1-11) to capture the subtleties of promoter-associated regions that only cover 1% of the genome, w”
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer (2012, positive): “Forkhead motifs are enriched within the regions bound by ER binding and multiple studies have identified the forkhead protein FOXA1 as an important pioneer factor for ER–chromatin interaction”
Modification of enhancer chromatin: what, how and why? (2013, background): “In support, in several cellular models, appearance of H3K4me1/2 was shown to coincide with binding of the pioneer TFs such as FOXA1 and PU.1 (Heinz et al., 2010; Sérandour et al., 2011).”
Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009 (2009, background): “steroid receptor cistrome, these studies have identified FOXA1 as an important component [8, 9].”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “About half of all ER-binding regions overlap with a FoxA1-binding region, suggesting significant genomic cooccupancy between the two factors (Carroll et al. 2005; Lupien et al. 2008; Hurtado et al. 2011).”
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities (2010, background): “, 2002), cooperative binding of one ormore factors toclustered sites that facilitates nucleosome displacement and stable binding of the factors involved (Boyes and Felsenfeld, 1996; Miller and Widom, 2003), and binding to chromatin marked in a cell type-specific manner by lysine 4-methylated histone”
Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer (2011, background): “…with the median distance between the respective binding peaks being 43 nt (range, 0–653 nt; Supplementary Figure S2), suggesting a global role of FoxA1 in androgen signalling and providing credence to the pioneering role of FoxA1 in AR binding to chromatin (Wang et al, 2007; Lupien et al, 2008).”