The IRF family transcription factors in immunity and oncogenesis.

By T. Tamura, H. Yanai, D. Savitsky, Tadatsugu Taniguchi. Annual Review of Immunology, 2008

1,310 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/7fe0bc65da91e09a7373044a98326b8610122c23

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Gasser
2. G. Shadel
3. W. Deng
4. Heiyoun Jung
5. Benjamin G. Gowen
6. Tadatsugu Taniguchi
7. M. Lamkanfi
8. Tuo Li

In Oncology

1. Tadatsugu Taniguchi
2. D. Raulet

Citations in the corpus

• Regulation of ligands for the NKG2D activating receptor (2013, background): “A connection between innate immune receptor engagement and NKG2D ligand expression was indicated by evidence that various agonists for TLRs induced Raet1 transcripts and cell surface RAE-1 protein in cultured macrophages (91).”
• Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA (2014, background): “Interferon regulatory factors (IRFs), and in particular IRF-3 and IRF-7, are major transcription factors required for the expression of type I IFNs (Tamura et al., 2008), and they are activated by the upstream kinase TBK1.”
• Peroxisomes are signaling platforms for antiviral innate immunity (2010, neutral): “IRF1, on the other hand, is needed for expression of all ISGs that we examined in VSV-infected cells and is not required for IFN expression (Tamura et al., 2008).”
• Inflammasomes and their roles in health and disease. (2012, background): “The consequent release of the cytoplasmic content into the extracellular space is thought to render pyroptosis proinflammatory, whereas apoptosis is generally considered an immunologically silent cell death mechanism (Lamkanfi 2011, Taylor et al. 2008).”
• Transcriptional control of adipose lipid handling by IRF4 (2011, neutral): “IRFs are a family of transcription factors involved in a wide range of immune functions, including lymphopoiesis, macrophage differentiation, and the regulation of innate immunity, particularly as effectors of toll-like receptor (TLR) signaling (Honda and Taniguchi, 2006; Tamura et al., 2008).”