VEGF targets the tumour cell

By H. Goel, A. Mercurio. Nature Reviews. Cancer, 2013

1,223 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/7fc3cbde0dca02e1eec419227e02945127d18af5

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In Molecular Biology

1. Richard J. Johnson
2. Huanhuan Chen
3. Li-li Zheng
4. Zhenling Liu
5. Li-Ping Sun
6. Lei Shi
7. G. Semenza

In Oncology

1. A. Poole
2. Ewelina Gołębiewska
3. V. Nizet

Citations in the corpus

• Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “VEGF-C,-D/VEGFR-3 is the primary signal pathway mediates lymphangiogenesis.(120) Blocking VEGF-C,-D/VEGFR-3 pathway has potential in preventing tumor metastasis.”
• Platelet secretion: From haemostasis to wound healing and beyond (2015, background): “vascular permeability, which promotes tumour cell extravasation [106], but was also recently implicated in the function of cancer stem cells and tumour initiation [107].”
• ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, neutral): “VEGF can also block the maturation of dendritic cells (Goel and Mercurio, 2013).”
• Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer (2019, background): “VEGF in Div-High tumors may induce polarization of CAFs, TAMs and TECs, and drive tumor progression (Goel and Mercurio, 2013; Kalluri, 2016; Pollard, 2004).”
• HIF Transcription Factors, Inflammation, and Immunity (2014, background): “Although it is accepted that VEGF contributes to tumorigenesis (Goel and Mercurio, 2013), when VEGF is specifically deleted in the myeloid lineage, spontaneous mammary PYMT tumors developed faster, as a result of blockade of the angiogenic switch and vascular normalization (Stockmann et al., 2008).”
• Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis (2014, neutral): “Shh alsomediates proangiogenic signaling by upregu- lating VEGF expression (Pola et al., 2003; Pola et al., 2001) and VEGF can induce expression of the Hh transcriptional activator Gli1 (Goel and Mercurio, 2013), suggesting the possible exis- tence of a positive feedback loop.”