Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.

By H. Braak, R. D. de Vos, J. Bohl, K. Del Tredici. Neuroscience Letters, 2006

1,339 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7f376c4b1f3f257ebbc010f8a10aba2ddeebcdcd

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In Neurology

Citations in the corpus

Gut microbiota are related to Parkinson's disease and clinical phenotype (2015, background): “DOI: 10.1002/mds.26069 350 Movement Disorders, Vol. 30, No. 3, 2015 be found in earliest stages of PD, sometimes years before motor symptoms appear, and therefore have been suggested as a premotor biomarker.3,6 Which factors initiate the pathophysiological cascade in PD is unknown, but an environmen”
Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders (2011, background): “…appearance of α -synuclein- containing Lewy bodies in the peripheral nervous system, and their relatively systematic spread within the brain 98, 99 , suggest that seeds-in-transit (i.e., those traveling between cells or from one region to another) might be profitable objectives for therapeutic…”
Diagnosis and treatment of Parkinson disease: molecules to medicine. (2006, background): “Indeed pathology is present outside of the brain as well, involving autonomic and submucosal ganglia (41, 42).”
Parkinson disease: from pathology to molecular disease mechanisms. (2013, background): “For example, constipation as a common NMS is associated with neuronal loss and the presence of Lewy bodies in the dorsal motor nucleus of the vagus, which provides parasympathetic innervation to the stomach and intestine [10,20,159], and changes such as these can be initiated by injection of proteas”
Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. (2016, background): “Current hypotheses suggest that the ENS might be one of the first sites where Lewy body pathology appears in PD [2,11].”
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice (2012, result): “In contrast to our model, however, the primary source of Syn nucleating seeds in PD and DLB remains unknown (Braak et al., 2006).”
α-Synuclein in Parkinson's disease. (2012, result): “This would be consistent with the findings of early enteric a-synuclein pathology in PD (Braak et al. 2006) and in asynuclein transgenic mice (Kuo et al. 2010).”
Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders (2010, positive): “However, as Lewy bodies and α-synuclein histopathology have been demonstrated to occur within sympathetic ganglia as well as intrinsic neurons of the enteric nervous system [17,54,69,80,81] an alternative explanation is that either or both of these have a selective rostrocaudal vulnerability to αsyn”
Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults (2008, background): “…CNS and PNS regions in these high-air-pollution–exposed young cohorts follows the characteristic topographical distribution of early PD lesions, as described by Braak and colleagues (Braak et al. 2003, 2006; Del Tredeci et al. 2002), that is, OB, lower brain stem, and ganglionic autonomic cells.”