Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.

By P. Birner, M. Schindl, A. Obermair, C. Plank, G. Breitenecker, G. Oberhuber. Cancer Research, 2000

659 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7f1579178f6a4f5fcf6418d038a709cd8140987c

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Citations in the corpus

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α (2009, background): “The presence of HIFs has been associated with poor outcome in a variety of different neoplasms (Birner et al., 2000; Aebersold et al., 2001; Semenza, 2003; Shimogai et al., 2008; Li et al., 2009).”
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. (2005, background): “HIF gene products collectively promote adaptation to hypoxia, and HIF-1α (or in some cases HIF-2α) is overexpressed in a majority of primary tumors, cancer cell lines, and metastases (Birner et al., 2000; Talks et al., 2000; Zhong et al., 1999).”
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy (2006, background): “Among patients with early stage cervical or endometrial cancers, who would normally be considered at low risk, those with high levels of HIF-1a expression show poorer outcomes (Birner et al. 2000).”
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. (2003, background): “HIFneck cancers (Aebersold et al., 2001; Beasley et al., 2002; Birner et al., 2000, 2001; Blancher et al., 2000; Bos et al., 2001; Giatro- 1␣ is rapidly degraded by the proteasome under normoxic conditions.”
Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “More interestingly, EMT-related signaling is not required for the metastatic process, but it promotes invasion, aging, cancer stem cell–like phenotype, and resistance to chemotherapy [46].”
The role of hypoxia-inducible factors in tumorigenesis (2008, methodology): “Cervical + ND HIF-1 Birner et al.(36) Gastric + ND HIF-1 Mizokami et al.”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “survival in cervical cancer (Birner et al., 2000), endometrial carcinoma (Sivridis et al.”