Insights into microtubule nucleation from the crystal structure of human γ-tubulin

By H. Aldaz, L. Rice, T. Stearns, David A. Agard. Nature, 2005

162 citations recorded by the source corpus.

Subfields: Global and Planetary Change, Insect Science, Plant Science

View Paper: https://www.semanticscholar.org/paper/7ef34ecb77b7071696cd069f75a8f3157b76e4cb

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1. Elizabeth H. Kellogg
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7. David A. Agard
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Citations in the corpus

• Microtubule nucleation: γ-tubulin and beyond (2006, background): “Within the crystal, GTP- -tubulin assumes a curved conformation (Aldaz et al., 2005) similar to that seen in unpolymerized GDP-bound tubulin (Ravelli et al., 2004) and in GDP-bound tubulin in curved protofilaments (Wang and Nogales, 2005).”
• Nature Reviews Molecular Cell Biology Microtubule nucleation by γ-tubulin complexes (2011, background): “The crystal structure of monomeric human γ-tubulin was determined bound to GTP and to GD”
• High resolution microtubule structures reveal the structural transitions in αβ–tubulin upon GTP hydrolysis (2014, background): “, 2011), supporting a model wherein lattice contacts, rather than nucleotide, controls tubulin conformation (Aldaz et al., 2005).”