The multifaceted biology of plasmacytoid dendritic cells

By M. Swiecki, M. Colonna. Nature reviews. Immunology, 2015

1,015 citations recorded by the source corpus.

Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7ecdfb366d6b3374d52aeea5cce45c46d5a8795f

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In Immunology

1. Aviv Regev
2. Rahul Satija
3. Nir Hacohen
4. S. Eisenbarth

Citations in the corpus

• Structure-function of the immune system in the spleen (2019, background): “After activation, pDCs rapidly secrete large amounts of type I interferons, IL-12 and IL-18, leading to increased natural killer T (NKT) cell activity, apoptosis of virally infected cells, and enhanced crosspriming [(43), review].”
• Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes and progenitors (2017, background): “Interestingly, pDCs andnc-cDCs require E2-2/TCF4 to develop, and reduced levels of E2-2 lead to higher ID2 and expression of cDC genes (18, 47, 48).”
• Mining the human gut microbiota for immunomodulatory organisms (2017, neutral): “Correspondingly, they have been implicated in several IFN-linked diseases (Swiecki and Colonna, 2015).”