Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

By I. Wood, P. Trayhurn. British Journal of Nutrition, 2003

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Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. (2005, background): “The bulk of filtered glucose is 90% reabsorbed by the low-affinity/high-capacity sodium glucose cotransporter (SGLT) 2 located in the S1 segments of proximal tubule (5).”
Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters (2007, background): “Interestingly, peripheral sites of GLUT3 expression include sperm, platelets, placenta, and certain human gliomas; all cell types that exhibit high rates of glucose metabolism (see Joost and Thorens, 2001; Uldry and Thorens, 2004; Wood and Trayhurn, 2003).”
Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control (2013, methodology): “placebo at 24 weeks; and (2) change from baseline in eGFR (Modification of Diet in Renal Disease Study equation (four-”