Monocyte differentiation and antigen-presenting functions

By Claudia V. Jakubzick, G. Randolph, P. Henson. Nature reviews. Immunology, 2017

799 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Developmental and Functional Heterogeneity of Monocytes. (2018, background): “Multiple studies have demonstrated that monocytes can take up, process, and present antigen in vivo but whether this contribution is significant to T cell priming compared to antigen-presentation by cDC is debatable and seems to depend on the inflammatory context (Jakubzick et al., 2017).”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “In the steady state, monocyte emigration occurs constitutively, where they can remain within the tissue as monocytes, acquire antigenpresenting capabilities, or mature into macrophages [59, 60].”
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases (2019, background): “Based on evidence originating from murine studies [reviewed in (1, 27)], but also recent human observations (28), it is now widely accepted that classical monocytes have the ability to differentiate into monocytederived macrophages (moMφs) and DCs (moDCs) (29) and play an integral part in shaping in”