Opinion: Angiogenesis: an organizing principle for drug discovery?

By J. Folkman. Nature reviews. Drug discovery, 2007

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Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “Angiogenesis mainly occurs in embryonic development, tissue repair, the menstrual cycle, muscle growth, and organ lining regeneration through a regular (strictly controlled by the body), scope-limited (occurs locally), and short-lived (days, weeks, or months) mode.(3,4) Nevertheless, angiogenesis wi”
Autocrine VEGF signaling is required for vascular homeostasis. (2007, positive): “In the adult, ample experimental evidence has unequivocally shown that VEGF is required for pathological growth of vessels in many conditions including inflammation, retinopathies, and arthritis (Dvorak, 2006; Hicklin and Ellis, 2005; Folkman, 2007).”
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases (2011, background): “However, blood vessels also nourish cancers and many other diseases, including age-related macular degeneration — the primary cause of vision loss in the elderl”
Interfering with pH regulation in tumours as a therapeutic strategy (2011, background): “The formation of new blood vessels from pre-existing ones (angiogenesis) provides oxygen and nutrients to the tumour, which are essential for tumour growt”