Biogenesis and function of extracellular vesicles in cancer.
By Maarten P. Bebelman, M. Smit, D. M. Pegtel, S. R. Baglio. Pharmacology and Therapeutics, 2018
707 citations recorded by the source corpus.
Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell "state" and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7de07133c424612761afbfc9333ff30c600825f0
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In Cancer Research
In Molecular Biology
Citations in the corpus
- Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis (2019, background): “The content, or cargo, of EVs consists of lipids, nucleic acids, and proteins—specifically proteins associated with the plasma membrane, cytosol, and those involved in lipid metabolism [1,4].”