Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

By P. Blanco, A. Palucka, M. Gill, V. Pascual, Jacques Banchereau. Science, 2001

625 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7dc3393a2177f84369c49b5e79aa2635ffaac686

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Frank O. Nestle
2. V. Delgado-Rizo
3. F. Allantaz
4. D. Golenbock
5. M. Punaro
6. Edsel Arce
7. M. A. Martínez-Guzmán
8. T. Means

Citations in the corpus

• Plasmacytoid predendritic cells initiate psoriasis through interferon-α production (2005, background): “An unabated activation of myeloid DCs through IFN- with the consequent activation of autoimmune T cells has been recognized as a key pathogenic event in SLE (13, 45).”
• Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade (2005, background): “RESULTS Incubation of healthy PBMCs with SoJIA serum up-regulates transcription of innate immunity genes We have previously shown that interferon- , which is present in the serum of patients who have systemic lupus erythematosus (SLE), induces the differentiation of healthy monocytes into dendritic ”
• Macrophages in immunoregulation and therapeutics (2023, background): “These dendritic cells can deliver autoantigens to autoreactive T cells and B cells.(256,262)”
• Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood (2003, background): “This study demonstrates that the majority (29/30) of children suffering from SLE display a signature of IFN exposure in their blood cells, therefore reinforcing the role of IFN- in the pathogenesis of this disease (15, 31, 32).”
• Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Furthermore, opsonized autoantigens induce pDCs to secrete IFN-α, also known as an “IFN-α signature,” and induce neutrophils to form NETs (133, 134).”
• Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “pDC numbers are reduced in SLE blood (Blanco et al., 2001), but these cells massively infiltrate inflamed lupus skin (Farkas et al.”
• Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. (2005, background): “It has been demonstrated that IFN-α in the serum of SLE patients drives the maturation of monocytes into DCs (48).”