Costimulation and endogenous MHC ligands contribute to T cell recognition

By C. Wülfing, C. Sumen, M. D. Sjaastad, Lawren C. Wu, Michael Loran Dustin, Mark M. Davis. Nature Immunology, 2002

144 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Quantitative challenges in understanding ligand discrimination by αβ T cells (2008, background): “On the other hand, recent findings have shown that self-pMHC ligands can sustain the sensitivity of the TCR signaling machinery [48] and during exposure to agonist ligands, enhance T cell responses at low foreign pMHC densities [48–51].”
T cell killing does not require the formation of a stable mature immunological synapse (2004, background): “3 ) and favoring those in which monomeric interactions or heterologous multimers formed between antigenic and endogenous pMHC complexes are the crucial trigge”