Tracking the ends: a dynamic protein network controls the fate of microtubule tips

By A. Akhmanova, M. Steinmetz. Nature reviews. Molecular cell biology, 2008

1,060 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/43c6e9f9ce7909fdc3c05b36e02531e0f009d355

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. L. A. Lowery
2. David Van Vactor
3. E. Dent
4. F. Gertler
5. C. Janke
6. S. Gupton

In Molecular Biology

1. L. A. Lowery
2. David Van Vactor
3. E. Dent
4. F. Gertler
5. C. Janke

Citations in the corpus

• The trip of the tip: understanding the growth cone machinery (2009, background): “One group of MAPs that has recently been shown to have a crucial role in growth cone dynamics is the family of plus-end tracking proteins (+TIPs; including end-binding proteins (EBs) and adenomatous polyposis coli ( APC )), which bind specifically to the plus ends of MT”
• A protein tagging system for signal amplification in gene expression and fluorescence imaging (2014, neutral): “…it is currently unclear whether individual Kif18b molecules track the growing plus ends by rapidly binding and releasing the plus end, as is the case for other plus-end tracking proteins (Akhmanova and Steinmetz, 2008) or whether it walks along the microtubule, remaining at the tip as it elongates.”
• The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance (2011, background): “Genetic interactions implicate b-Spectrin in SLIT/ROBO-mediated midline repulsion as well (Garbe et al. 2007a).”
• Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions (2011, background): “Another group of intensively studied MAPs is that of the microtubule plus end-tracking proteins (+TIPs), which help to control microtubule dynamics and interactions with other cellular organelles and subcellular domain”
• An EB1-binding motif acts as a microtubule tip localization signal. (2009, neutral): “Regulation of Microtubule Tip Localization by Phosphorylation +TIPs are frequently the target of kinases at multiple sites ( Akhmanova and Steinmetz, 2008 ).”