Alternative splicing: a pivotal step between eukaryotic transcription and translation

By A. Kornblihtt, Ignacio E Schor, Maria Alló, Gwendal Dujardin, E. Petrillo, M. Muñoz. Nature reviews. Molecular cell biology, 2013

829 citations recorded by the source corpus.

Alternative splicing was discovered simultaneously with splicing over three decades ago. Since then, an enormous body of evidence has demonstrated the prevalence of alternative splicing in multicellular eukaryotes, its key roles in determining tissue- and species-specific differentiation patterns, the multiple post- and co-transcriptional regulatory mechanisms that control it, and its causal role in hereditary disease and cancer. The emerging evidence places alternative splicing in a central position in the flow of eukaryotic genetic information, between transcription and translation, in that it can respond not only to various signalling pathways that target the splicing machinery but also to transcription factors and chromatin structure.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7d148abd3ca562cd3b81ba5071e36fe8d17f32eb

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Citations in the corpus

Widespread intron retention in mammals functionally tunes transcriptomes (2014, background): “…re- cruitment to sites of active transcription through coupling mechanisms that involve chromatin and transcription factors (Braunschweig et al. 2013; Kornblihtt et al. 2013), including splicing activators and the Pol II carboxyl-terminal domain (David andManley 2011), it is possible that reduced…”
A census of human RNA-binding proteins (2014, background): “example, the abundance of various splicing factors can influence mRNA splicing patterns (Chen and Manley, 2009; Kalsotra and Cooper, 2011; Kornblihtt et al., 2013; Smith and Valcarcel, 2000; Wahl et al., 2009), while U1 snRNP levels control alternative polyadenylation sites (Berg”
Efficient backsplicing produces translatable circular mRNAs (2015, background): “, linear splicing) of most metazoan introns requires a stepwise assembly of spliceosomal components in a cotranscriptional fashion (Kornblihtt et al. 2013; Matera and Wang 2014), starting with a process called exon definition in which the 5′ ss and 3′ ss are recognized in pairs across exons through ”
Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses[OPEN] (2013, background): “Around 15% of genetic diseases are due to mutations which affect splicing (Kornblihtt et al., 2013).”
circRNA biogenesis competes with pre-mRNA splicing. (2014, background): “RNA pol II can also influence pre-mRNA processing through changes in the transcription elongation rate, a well-characterized modulator of alternative splicing (Kornblihtt et al., 2013).”
Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing (2019, background): “The current point of view ascribes this function to the carboxy-terminal domain (CTD) of the largest RNA pol II subunit (9,15).”