Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
By H. Pel, J. H. Winde, D. Archer, P. Dyer, G. Hofmann, P. Schaap, G. Turner, R. D. Vries, R. Albang, K. Albermann and 59 more. Nature Biotechnology, 2007
1,185 citations recorded by the source corpus.
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/52922a4d61df78d722716a77d49d814a0ea5049e
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Citations in the corpus
- Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum (2011, background): “These families are also expanded in some Aspergilli, where the characterized examples are involved in regulating diverse aspects of primary and secondary metabolism, including protein and polysaccharide degradation [70].”
- Fungal Secondary Metabolism (2012, neutral): “The fi gure shows different sections of the input screen including (1) buttons to load a sample input fi le or open an example output fi le; (2) optional input for an e-mail address, where results can be sent; (3) input fi le options for GBK/EMBL/FASTA fi les and genome accession numbers; (4) a chec”
- Gene targeting in filamentous fungi: the benefits of impaired repair (2007, background): “With the recently disclosed genome sequence of this filamentous fungus (Pel et al. 2007), NHEJ-deficient A.”