Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

By Jeong Woong Lee, K. Beebe, L. Nangle, Jaeseon Jang, Chantal M. Longo-Guess, Susan A. Cook, M. Davisson, J. Sundberg, P. Schimmel, S. Ackerman. Nature, 2006

599 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7cc7beec128e72f60826b9428c36eb2479836c7d

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In Molecular Biology

1. M. Molinari
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Citations in the corpus

• Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution (2008, unknown): “Malfunctioning of broadly expressed proteins involved in translation and protein folding manifests specifically neurotoxic effects in mouse (Lee et al., 2006; Zhao et al., 2005).”
• In and out of the ER: protein folding, quality control, degradation, and related human diseases. (2007, background): “Errors are caused by misacylation leading to tRNAs loaded with the inappropriate amino acid (221), by selection of an incorrect tRNA during the elongation process (176, 231), by incorrect selection of the start codon, by frame shifts, or by incorrect terminations.”