Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism

By Daftar Pustaka Assob, J.C.N, Ngowe, M.-N, Nsagha, D.S, Njunda, L. Anna, Waidin, R.J. and 7 more. HYPERTENSION, 2001

1,370 citations recorded by the source corpus.

Subfields: Nephrology, Pathology and Forensic Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/7ca83b05e0bb33f24852463eb8eee197e6945c3d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nephrology

1. Richard J. Johnson
2. Y. Sautin
3. D. Kang
4. D. Feig
5. H. Lan
6. J. Hare
7. C. Berry

In Pathology and Forensic Medicine

1. F. B. Hu
2. Guy C. Brown
3. Chris E. Cooper

In Pharmacology

1. Richard J. Johnson
2. P. Pacher

Citations in the corpus

• Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. (2002, methodology): “An unexpected finding in this model was the observation that mild hyperuricemia induced a blood pressure elevation after several weeks (14).”
• Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol (2006, background): “There is evidence that elevated uric acid levels correlate with the increase in blood pressure in rats (Mazzali et al., 2001).”
• Hyperuricemia induces endothelial dysfunction. (2005, background): “Rats administered an uricase inhibitor (oxonic acid) develop mild hyperuricemia, hypertension, and vascular disease that is mediated by activation of the reninangiotensin system, a loss of macula densa NOS, and the development of microvascular disease [6].”
• Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications (2004, background): “Oxonic acid-treated rats also develop renal injury attenuated by enalapril or l-arginine (Mazzali et al. 2001).”
• Determination of ascorbic acid, dopamine, and uric acid by a novel electrochemical sensor based on pristine graphene (2015, background): “UA is also a vital biomolecule which consists in urine and blood [10].”
• Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. (2007, background): “For example, mildly hyperuricemic rats develop hypertension because of the inhibition of nitric oxide synthase in the macula densa, the stimulation of intrarenal renin, and a reduction in endothelial nitric oxide bioavailability (67).”
• Uric acid and chronic kidney disease: which is chasing which? (2013, background): “For one thing, uric acid stimulates the production of angiotensin II in vascular cells and also increases renin expression in laboratory animals [10, 19, 71].”
• Hyperuricemia and Incident Hypertension: A Systematic Review and Meta-Analysis (2011, background): “The renal lesions and hypertension were prevented by lowering uric acid levels with allopurinol or benziodarone (a uricosuric agent) and reversed by angiotensin-converting enzyme inhibition (6).”
• A role for uric acid in the progression of renal disease. (2002, methodology): “The doses of AP and BZ were determined on the basis of the uric acid-lowering effect in previous studies (9,10).”