Finding function in novel targets: C. elegans as a model organism

By Titus Kaletta, Michael O. Hengartner. Nature reviews. Drug discovery, 2006

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Commercial extract of the brown seaweed Ascophyllum nodosum enhances phenolic antioxidant content of spinach (Spinacia oleracea L.) which protects Caenorhabditis elegans against oxidative and thermal stress (2011, background): “The nematode Caenorhabditis elegans, a simple yet sophisticated multicellular animal which has become an important model organism for the study of biological processes due to its easy culture conditions, short generation time and lifespan, and experimental flexibility (Kaletta & Hengartner, 2006).”
A Transparent Window into Biology: A Primer on Caenorhabditis elegans (2015, background): “…genes have predicted orthologs in the human genome (Shaye and Greenwald 2011), 60–80% of human genes have an ortholog in the C. elegans genome (Kaletta and Hengartner 2006), and 40% of genes known to be associated with human diseases have clear orthologs in the C. elegans genome (Culetto and…”
Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, methodology): “While most RNAi screens have been done in wild-type C. elegans, some are performed using KO mutants to provide more sensitive or selective assays (Kaletta and Hengartner, 2006).”