Chronic Anterior Thalamus Stimulation for Intractable Epilepsy

By M. Hodaie, R. Wennberg, J. Dostrovsky, Andres M. Lozano. Epilepsia, 2002

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Patient-specific analysis of the volume of tissue activated during deep brain stimulation (2007, background): “It has also been used to treat various other neurological conditions including depression (Mayberg et al., 2005), obsessive–compulsive disorder (Gabriels et al., 2003) and epilepsy (Hodaie et al., 2002).”
Deep brain stimulation for treatment-resistant depression. (2005, positive): “…DBS discontinuation has been observed in other disorders targeting different brain circuits, including epilepsy, essential tremor, dystonia, and Parkinson’s disease (Hodaie et al. 2002, Kumar et al. 2003; Deep-Brain Stimulation for Parkinson’s Disease Study Group, 2001; Vidailhet et al., 2005).”
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy (2010, background): “…the initially positive results in the studies of Cooper (Cooper et al., 1980, 1984), three unblinded pilot trials before (Sussman et al., 1988; Hodaie et al., 2002; Kerrigan et al., 2004), and subsequently, three after (Lee et al., 2006; Lim et al., 2007; Osorio et al., 2007) the randomized…”
Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. (2004, background): “In addition, multiple pilot studies have begun to examine the utility of DBS for dystonia (Coubes et al., 2000; Yianni et al., 2003), epilepsy (Hodaie et al., 2002), and obsessive-compulsive disorder (OCD) (Gabriels et al., 2003).”