Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia.

By Peder Buchhave, Lennart Minthon, Henrik Zetterberg, Å. Wallin, Kaj Blennow, Oskar Hansson. Archives of General Psychiatry, 2012

656 citations recorded by the source corpus.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/7c215fda105b21515303373cf2dcd8b482648425

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. Kaj Blennow
2. Philip Scheltens
3. Bruno Dubois
4. Reisa A. Sperling
5. Clifford R. Jack Jr.
6. Lars Bertram
7. Henrik Zetterberg

In Physiology

1. Kaj Blennow
2. Reisa A. Sperling
3. Harald Hampel
4. Clifford R. Jack Jr.
5. P. Aisen
6. Philip Scheltens
7. Marie Odile Habert
8. C. Duyckaerts

In Psychiatry and Mental health

1. Kaj Blennow
2. Reisa A. Sperling
3. Harald Hampel
4. Clifford R. Jack Jr.
5. P. Aisen
6. Philip Scheltens
7. C. Duyckaerts
8. Bruno Dubois

Citations in the corpus

• Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease (2017, neutral): “CSF Aβ42, mean (SD), ng/L 207 (52) 165 (52) 134 (23) <.”
• Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria (2016, background): “This construct has also been validated in those asymptomatic at risk for clinical AD (AR-AD), where altered CSF levels of AP biomarkers or brain amyloidopathy as seen on PET can precede the occurrence of the prodromal or dementia stage by several years [5].”