Night-shift work and risk of colorectal cancer in the nurses' health study.
By E. Schernhammer, Francine Laden, F. Speizer, W. Willett, D. Hunter, Ichiro Kawachi, C. Fuchs, Graham A Colditz. Journal of the National Cancer Institute, 2003
828 citations recorded by the source corpus.
Exposure to light at night suppresses the physiologic production of melatonin, a hormone that has antiproliferative effects on intestinal cancers. Although observational studies have associated night-shift work with an increased risk of breast cancer, the effect of night-shift work on the risk of other cancers is not known. We prospectively examined the relationship between working rotating night shifts and the risk of colorectal cancers among female participants in the Nurses' Health Study. We documented 602 incident cases of colorectal cancer among 78 586 women who were followed up from 1988 through 1998. Compared with women who never worked rotating night shifts, women who worked 1-14 years or 15 years or more on rotating night shifts had multivariate relative risks of colorectal cancer of 1.00 (95% confidence interval [CI] = 0.84 to 1.19) and 1.35 (95% CI = 1.03 to 1.77), respectively (P(trend) =.04). These data suggest that working a rotating night shift at least three nights per month for 15 or more years may increase the risk of colorectal cancer in women.
Subfields: Endocrine and Autonomic Systems, Experimental and Cognitive Psychology
View Paper: https://www.semanticscholar.org/paper/7bfbc913e8287b5e1ef3e2830aa0e6dd7ad83383
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In Endocrine and Autonomic Systems
In Experimental and Cognitive Psychology
Citations in the corpus
- Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption (2017, background): “The data suggest that working a rotating night shift at least three nights per month for 15 or more years may increase the risk of colorectal cancer in women [85].”
- The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. (2006, background): “Per1 Is Downregulated in Human Tumors The view of the circadian clock as a systemic tumor suppressor in humans is supported by epidemiological studies documenting increased incidence of breast and colon cancer in women working night shifts (Hansen, 2001; Schernhammer et al., 2003).”
- Negative Impacts of Shiftwork and Long Work Hours (2014, background): “Schernhammer et al. (2003) reported an increased risk of colon cancer in nurses working three or more nights per month for 15 or more years.”
- Short- and long-term health consequences of sleep disruption (2017, neutral): “The mechanisms responsible for carcinogenesis in sleepdisrupted individuals are not clear, and much of the work is focused on nighttime light exposure and decreased melatonin levels.(92,93) Additional research is required to determine the effect and etiology of sleep disruption on cancer risk.”
- The influence of bio-behavioural factors on tumour biology: pathways and mechanisms (2006, background): “Night-time shift work, a condition that is known to disrupt endocrine rhythms, is a risk factor for breast and colorectal cance”