Multifunctional magnetic nanoparticles for targeted imaging and therapy.

By J. McCarthy, Ralph Weissleder. Advanced Drug Delivery Reviews, 2008

868 citations recorded by the source corpus.

Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials.

Subfields: Biomaterials, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/7be3de985b0f2c13c0a6a0d751a6f33a2c603406

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In Biomaterials

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5. Bengt Fadeel
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8. S. A. Hamid

In Molecular Biology

1. S. Bagheri
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In Radiology, Nuclear Medicine and Imaging

1. Miqin Zhang

Citations in the corpus

• Iron Oxide Nanoparticles: Diagnostic, Therapeutic and Theranostic Applications (2019, background): “Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6,7,13,14], hyperthermia [15–17], biose”
• Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging (2009, background): “Currently, a number of SPIONs are in early clinical trials or experimental study stages [8,9, 15], and several formulations have been approved for clinical use for medical imaging and therapeutic applications.”
• Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. (2010, background): “For excellent reviews on other classes of inorganic nanoparticles including quantum dots and iron oxide nanoparticles envisioned for medical imaging and treatment, the reader is referred to recent issues of this journal [4,5].”