The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
By Stephen R. Quake. bioRxiv, 2021
1,081 citations recorded by the source corpus.
Molecular characterization of cell types using single cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues and tissue specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, the tissue specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type specific RNA splicing was discovered and analyzed across tissues within an individual.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e98dba76d265d4257138cd311734a624d339a006
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In Immunology
In Molecular Biology
- Tim Stuart
- Rahul Satija
- Saket Kumar Choudhary
- Avi Srivastava
- Shaista Madad
- Paul J. Hoffman
- Fabian J Theis
Citations in the corpus
- Dictionary learning for integrative, multimodal, and massively scalable single-cell analysis (2022, positive): “For example, the Human Cell Atlas, Human Biomolecular Atlas Project, Tabula Sapiens 68 and Human Cell Landscape 69 have all released scRNA-seq references spanning hundreds of thousands of cells for multiple human tissues.”
- Large Scale Foundation Model on Single-cell Transcriptomics (2023, neutral): “Ablation experiments showed that such asymmetric design reduced the computational and memory challenges compared with other architectures (Supplementary Table 6).”