Dosage-sensitive requirement for mouse Dll4 in artery development.
By A. Duarte, M. Hirashima, Rui Benedito, A. Trindade, P. Diniz, E. Bekman, L. Costa, D. Henrique, Janet Rossant. Genes & Development, 2004
600 citations recorded by the source corpus.
Involvement of the Notch signaling pathway in vascular development has been demonstrated by both gain- and loss-of-function mutations in humans, mice, and zebrafish. In zebrafish, Notch signaling is required for arterial identity by suppressing the venous fate in developing artery cells. In mice, the Notch4 receptor and the Delta-like 4 (Dll4) ligand are specifically expressed in arterial endothelial cells, suggesting a similar role. Here we show that the Dll4 ligand alone is required in a dosage-sensitive manner for normal arterial patterning in development. This implicates Dll4 as the specific mammalian endothelial ligand for autocrine endothelial Notch signaling, and suggests that Dll4 may be a suitable target for intervention in arterial angiogenesis.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7bb337e0409a9ee5d6ed59475b1a8a8bb6c27dfb
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Molecular Biology
- S. Artavanis-Tsakonas
- E. Dejana
- Leigh Coultas
- B. Weinstein
- K. Chawengsaksophak
- A. Louvi
- Janet Rossant
Citations in the corpus
- Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “DLL4 mutations in mice result in severe disruption of the vasculature”
- The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. (2009, background): “, 2000), Notch ligand Dll4 (Duarte et al., 2004; Gale et al., 2004; Krebs et al., 2004), Notch effector Rbpj and Mib, and Hey1/Hey2 double mutants (Fischer et al.”
- Endothelial cells and VEGF in vascular development (2005, background): “However, mutations in Dll4, which is a Notch ligand specifically expressed in developing arterial but not venous endothelium, lead to defective development of the dorsal aorta and cardinal veins, with development of arterio-venous shunt”
- Notch signalling in vertebrate neural development (2006, background): “Development is extraordinarily sensitive to the dosage of Notch signalling, as has been revealed by various studies involving different expression levels of Notch pathway element”