Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China

By Yue-ying Pan, Hanxiong Guan, Shuchang Zhou, Yujin Wang, Qian Li, Tingting Zhu, Qiongjie Hu, L. Xia. European Radiology, 2020

946 citations recorded by the source corpus.

Objectives The purpose of this study was to observe the imaging characteristics of the novel coronavirus pneumonia. Methods Sixty-three confirmed patients were enrolled from December 30, 2019 to January 31, 2020. High-resolution CT (HRCT) of the chest was performed. The number of affected lobes, ground glass nodules (GGO), patchy/punctate ground glass opacities, patchy consolidation, fibrous stripes and irregular solid nodules in each patient's chest CT image were recorded. Additionally, we performed imaging follow-up of these patients. Results CT images of 63 confirmed patients were collected. M/F ratio: 33/30. The mean age was 44.9 ± 15.2 years. The mean number of affected lobes was 3.3 ± 1.8. Nineteen (30.2%) patients had one affected lobe, five (7.9%) patients had two affected lobes, four (6.3%) patients had three affected lobes, seven (11.1%) patients had four affected lobes while 28 (44.4%) patients had 5 affected lobes. Fifty-four (85.7%) patients had patchy/punctate ground glass opacities, 14 (22.2%) patients had GGO, 12 (19.0%) patients had patchy consolidation, 11 (17.5%) patients had fibrous stripes and 8 (12.7%) patients had irregular solid nodules. Fifty-four (85.7%) patients progressed, including single GGO increased, enlarged and consolidated; fibrous stripe enlarged, while solid nodules increased and enlarged. Conclusions Imaging changes in novel viral pneumonia are rapid. The manifestations of the novel coronavirus pneumonia are diverse. Imaging changes of typical viral pneumonia and some specific imaging features were observed. Therefore, we need to strengthen the recognition of image changes to help clinicians to diagnose quickly and accurately. Key Points • High-resolution CT (HRCT) of the chest is critical for early detection, evaluation of disease severity and follow-up of patients with the novel coronavirus pneumonia . • The manifestations of the novel coronavirus pneumonia are diverse and change rapidly . • Radiologists should be aware of the various features of the disease and temporal changes .

Subfields: Dermatology, Infectious Diseases, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/7b811119a5007ff264567c42f9090c1eb9bdf153

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Z. Ye
2. L. Xia
3. Yuhui Wang
4. Feng He
5. Yun Zhang
6. C. Dong
7. Yi Wang
8. Yu Deng

Citations in the corpus

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• Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review (2020, background): “As reported, 3~13% of COVID-19 patients can appear with multifocal solid irregular nodules [16, 21] or nodules with visible halo sign [34].”
• Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID‐19) implicate special control measures (2020, background): “patients with mild/moderate symptoms can quickly transit into severe or critical statuses if without immediate care.(40) These virus‐”
• Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. (2020, neutral): “They found that more than 85% of the patients showed imaging signs associated with disease progression such as increase in GGO, consolidative opacities, and interstitial septal thickening (referred to as “enlarged fibrous stripes”) [6].”
• Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis (2020, neutral): “Eur Radiol 02/13 China Cross-sectional 63 14 [72]”
• Coronavirus disease 2019: What we know? (2020, background): “A little fibrous stripe may appear if the condition was improved.(37) One report suggested that there are four stages defined on CT scan.”
• Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths (2020, neutral): “In contrast, a small fibrous stripe, as well as the resolution of GGO, may be associated with improvement in the patient’s condition.(28,29)”
• Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases (2020, methodology): “Based on available data published in recent literature, almost all patients with COVID-19 had characteristic CT features in the disease process (8, 10-13), such as different degrees of ground-glass opacities with/without crazy-paving sign, multifocal organizing pneumonia, and architectural distortio”
• Coronavirus Disease 2019 (COVID-19): A Perspective from China (2020, background): “Pleural effusion, lung cavitation, lymphadenopathy and calcification are rarely reported (40-44,49-50).”
• Work stress among Chinese nurses to support Wuhan in fighting against COVID‐19 epidemic (2020, background): “The COVID-19 epidemic has posed a remarkable threat to public health (Pan et al., 2020).”