Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis
By Alfonso J Rodriguez-Morales, J. Cardona-Ospina, Estefanía Gutiérrez-Ocampo, Rhuvi, Villamizar-Peña, Yeimer Holguin-Rivera, J. P. Escalera-Antezana, L. E. Alvarado-Arnez, Katterine Bonilla-Aldana, C. Franco-Paredes and 16 more. Travel Medicine and Infectious Disease, 2020
2,105 citations recorded by the source corpus.
Introduction An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date. Methods We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate pooled prevalences and 95% confidence intervals (95%CI). Results 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5–92.9%), cough (57.6%, 95%CI 40.8–74.4%) and dyspnea (45.6%, 95%CI 10.9–80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0–30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7–51.8), 6.2% (95%CI 3.1–9.3) with shock. Some 13.9% (95%CI 6.2–21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR). Conclusion COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of >13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.
Subfields: Infectious Diseases, Neurology
View Paper: https://www.semanticscholar.org/paper/8ec7e4858cbcd6429aa2f30902a819a18e0b8c88
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Infectious Diseases
Citations in the corpus
- Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 (2020, background): “13 The disease case fatality rate (CFR) varies depending on region, population demographics, and heath care capabilities; for instance, in Italy an overall CFR of 7.2% is estimated, in part driven by the higher proportion of individuals of advanced age compared to China. 14 On the basis of global da”
- Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) (2020, positive): “Secondary infections occur in patients with COVID-19, but the incidence is unknown given the very limited data [159].”
- Coronavirus (COVID-19) (2020, background): “X-ray abnormalities peak at 10–12 days after onset of symptoms [94, 220].”
- The Role of Imaging in the Detection and Management of COVID-19: A Review (2020, background): “These imaging interpretations played a key role not only in the diagnosis of COVID-19 but also in the monitoring of disease progression and the evaluation of therapeutic efficacy [15], [16].”
- Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study (2020, positive): “Under CT, patients with COVID-19 may have some resi dual fibrotic lesions in the lungs following current treatment and discharge pro toc ls [7], which may affect the patient’s respiratory function.”
- The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries (2020, background): “For those articles not uploading a preprint, the delay from searching to publication was 3 weeks [10].”
- COVID-19 length of hospital stay: a systematic review and data synthesis (2020, neutral): “Hospital care can vary from general ward based care to high dependency units with oxygen support to intensive care where patients may be intubated for mechanical ventilation [8] [9] [10] .”