CRF and CRF receptors: role in stress responsivity and other behaviors.

By T. Bale, W. Vale. Annual Review of Pharmacology and Toxicology, 2004

1,283 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Physiology

View Paper: https://www.semanticscholar.org/paper/7b5033b533ba5feeb137ccdfbe1381d1b5dd961d

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Citations in the corpus

Epigenetics and the biological definition of gene x environment interactions. (2010, background): “CRF acts at CRF1 receptors in the locus coeruleus to stimulate the release of norepinephrine in a variety of corticolimbic structures (Bale & Vale, 2004; Valentino, Curtis, Page, Pavcovich, & Florin-Lechner, 1998).”
The neurobiology of stress and development. (2007, background): “Patterns of social relatedness in infancy can be characterized, in part, by the security of the infant-caregiver attachment relationship (Ainsworth et al. 1978), and physiological stress responses have been found to be mediated by attachment security (Gunnar et al. 1996, Spangler & Schieche 1998,…”
The story of Rett syndrome: from clinic to neurobiology. (2007, positive): “Crh is an attractive candidate in the investigation of therapeutic intervention strategies in RTT given that Crh receptor 1 (Crhr1) antagonists have been shown to reduce anxiety (Bale and Vale, 2004).”
Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “…that CRF is an essential neuromodulator in a number of core limbic regions, including the hypothalamus, the amygdala, the septum, limbic and midline thalamic areas, the bed nucleus of stria terminalis (BNST), and paralimbic paleocortical areas such as the cingulate and insula (Bale & Vale, 2004).”
Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017, background): “There are two main types of the CRH receptor in mammals, although the CRH-R1 is the primary receptor responsible for driving secretion of ACTH from corticotrophs.”
Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy (2008, background): “CRF is a known regulator of 5-HT neurotransmission and a key determinant of stress responsivity (Valentino et al., 1991; Bale and Vale, 2004; Tan et al., 2004).”
Psychobiological Mechanisms Underlying the Social Buffering of the HPA Axis: A Review of Animal Models and Human Studies across Development (2013, background): “In this regard, it is noteworthy that CRH-producing cells do not reside exclusively in the hypothalamus, but they are also present in many brain structures that are involved in associating fear and anxiety with activation of the stress system, including the CEA and the PFC (Bale & Vale, 2004).”
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System (2008, background): “The CRF receptor system is comprised of peptide ligands CRF and urocortin I, which act on the CRF1-receptor (CRF1-R) and the peptides urocortin II and urocortin III that are selective for CRF2-receptors (CRF2-R) (Bale and Vale, 2004).”
A role for brain stress systems in addiction. (2008, positive): “The discovery of other peptides with structural homology, notably the urocortin family (urocortins 1, -2, and -3), has suggested broad neurotransmitter roles for the CRF systems in behavioral and autonomic responses to stress (Bale and Vale, 2004) (see Supplemental Data available online).”