The in vitro micronucleus technique.

By Michael Fenech. Mutation research, 2000

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Determination of genotoxic effects of chlorfenvinphos and fenbuconazole in Allium cepa root cells by mitotic activity, chromosome aberration, DNA content, and comet assay (2012, background): “An aneugenic and/or clastogenic activity are attributed to the presence of micronucleated cells as stated in the study Fenech [40].”
Allium Cepa Root Chromosomal Aberration Assay: A Review (2013, neutral): “in the formation of micronucleated cells, since both fragments and entire chromosomes cannot be incorporated into the main nucleus during the cell cycle [13].”
HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. (2003, methodology): “The increased use of the CBMN assay in combination with chromosome specific centromeric probes to measure chromosome loss and non-disjunction [2] also requires standardisation in terms of how probe signals are accepted, rejected and quantified if comparison of results from such tests among laborator”
NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Additionally, nucleoplasmic bridges (a biomarker of chromosome rearrangement) and nuclear buds (a biomarker of amplified DNA) can be scored in the binucleated cells, as can assessment of cytostatic effects, apoptosis and cytotoxicity [199–201].”