Systems biology, metabolic modelling and metabolomics in drug discovery and development.

By Douglas B. Kell. Drug Discovery Today, 2006

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The Edinburgh human metabolic network reconstruction and its functional analysis (2007, background): “Recent rapid developments of advanced metabolomics technology is opening up new horizons, as hundreds or even thousands of metabolites can be measured simultaneously, providing a much more comprehensive assessment of a patient’s health status (Griffin and Nicholls, 2006; Kell, 2006; Wishart et al,”
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, background): “al., 2012). Reconstruction of metabolic networks became a highly integrative process, which applies genome sequences, enzyme databases, and speciﬁes the network using transcriptome and proteome data (Kell, 2006; Ma & Goryanin, 2008). In the last decade several metabolic networks, such as those o”
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology (2008, methodology): “It can also be used in metabolic flux estimation based on isotopomer data 59 , for filling gaps in metabolic pathways and for exploring questions related to comparative metabolomics 60 and of metabolic pathway evolution.”