Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome.

By M. Alpert. American Journal of the Medical Sciences, 2001

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Myocardial fatty acid metabolism in health and disease. (2010, background): “While patients with obesity have an increased risk for ischemic heart disease, a significant proportion of these patients will develop heart failure independent of ischemia (13, 694).”
Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. (2009, background): “Reprinted, with permission, from Alpert ( 14 ).”
2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. (2013, background): “A subsequent, persistent increase in cardiac output, cardiac work, and systemic blood pressure (124) along with lipotoxicity-induced cardiac myocyte injury and myocardial lipid accumulation have been implicated as potential mechanisms (125,126).”
The medical complications of obesity. (2006, background): “Individuals with obesity have a form of cardiomyopathy attributed to chronic volume overload, characterized by left ventricular dilatation, increased left ventricular wall stress and compensatory left ventricular hypertrophy.(49) Most studies have reported abnormal diastolic function(50,51) without ”