Myocardial fatty acid metabolism in health and disease.

By G. Lopaschuk, J. Ussher, C. Folmes, Jagdip S. Jaswal, W. Stanley. Physiological Reviews, 2010

2,101 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/379452c179bb09ea7bcf7149ea5e556407ba3f7d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Rong Tian
2. E. Dale Abel
3. Bo Zhou
4. S. Verma
5. P. Crawford
6. Adam R. Wende
7. Patrycja Puchalska
8. Qutuba G. Karwi

In Molecular Biology

1. Rong Tian
2. E. Dale Abel
3. S. Verma
4. P. Crawford
5. R. Wanders
6. Patrycja Puchalska

In Physiology

1. Sander M. Houten
2. P. Crawford
3. F. V. Ventura
4. R. Wanders
5. Patrycja Puchalska
6. S. Violante

Citations in the corpus

• Cardiac Metabolism in Heart Failure - Implications beyond ATP production (2013, neutral): “In the cytosol, free FAs are esterified to fatty acyl-coenzyme A (CoA), which is either esterified to triglyceride or converted to long-chain acylcarnitine by carnitine palmitoyltransferase (CPT) I located in the outer mitochondrial membrane before entering the mitochondria.(9,11) The turnover of th”
• Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “HEXIM1-induced hypertrophy was associated with the regulation of transcription factors, which regulate angiogenesis (e.g., HIF1-α, VEGF) and metabolism [PPAR-α, glucose transporter type 4 (GLUT4)].”
• Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors (2020, background): “As heart failure progresses, a continual decline in mitochondrial oxidative metabolism occurs, and the heart becomes more reliant on glycolysis as a source of energy (25).”
• Mitochondrial dysfunction in pathophysiology of heart failure (2018, background): “This is accomplished by oxidative metabolism in mitochondria using fatty acids as the primary fuel (27, 28).”
• The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders. (2016, background): “Diabetes and obesity also have significant consequences for cardiac metabolism, with increased fatty acid uptake and oxidation possibly contributing to the increased risk of cardiovascular disease (37).”
• Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics (2017, background): “…pathological ventricular remodeling are under investigation. hypertension or myocardial infarction) and the diabetic heart each become metabolically inflexible (Balasse and Féry, 1989; Bing, 1954–1955; Fukao et al., 2004; Lopaschuk et al., 2010; Taegtmeyer et al., 1980, 2002; Young et al., 2002).”
• Cardiac Energy Metabolism in Heart Failure (2021, methodology): “This can be achieved by increasing circulating ketone body levels, primarily by one of the 4 following approaches: (1) ketone infusions, (2) ketone ester administration, (3) SGLT2 (sodium/glucose co-transporter 2) inhibitors, and (4) administration of a ketogenic diet.”