Protease inhibitors: current status and future prospects.

By Donmienne Leung, G. Abbenante, D. Fairlie. Journal of Medicinal Chemistry, 2000

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Characteristics of Plant Proteinase Inhibitors and Their Applications in Combating Phytophagous Insects (2005, neutral): “cell signaling/migration, digestion, fertilization, growth, differentiation, immunological defense, wound healing and apoptosis, have great potential in therapeutic applications (Abdel-Meguid, 2000; Leung et al., 2000).”
In silico pharmacology for drug discovery: applications to targets and beyond (2007, background): “There has been a brief overview of Cathepsin D in a comprehensive review of protease inhibitors (Leung et al ., 2000).”
Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. (2001, background): “The serine protease, hepsin, which we and others (16) find up-regulated in all of the primary tumors examined, is a potential drug target (17).”
Considerations for the design and reporting of enzyme assays in high-throughput screening applications (2014, background): “Proteases are a well-established class of drug targets (Leung et al., 2000) and have received considerable coverage in terms of assay formats and reagent kits.”