Modulation of glutathione and its related enzymes in plants’ responses to toxic metals and metalloids—A review
By Naser Anjum, Iqbal Ahmad, I. Mohmood, M. Pacheco, Armando C. Duarte, E. Pereira, Shahid Umar, Altaf Ahmad, N. Khan, M. Iqbal and 1 more. 2011
401 citations recorded by the source corpus.
Abstract The rapid increase in the contamination of the environment by toxic metals (TMs) and metalloids is posing serious threats to biotic communities. Plants are among the organisms most vulnerable to TMs and metalloids due to their sedentary and stationary existence under changing environmental conditions. Toxic metals- and metalloids-stress-impacts cause either directly or indirectly excessive generation of reactive oxygen species (ROS) leading to oxidative stress in plants. Being a significant component of ascorbate-glutathione (AsA-GSH) pathway, tripeptide glutathione (GSH, γ-Glu-Cys-Gly) is involved in both direct and indirect control of ROS and their reaction products concentrations in cells and thus, protects plants against TMs- and metalloids-mediated oxidative stress. Additionally, several GSH-related enzymes such as GSH reductase (GR, EC 1.6.4.2), GSH peroxidases (GPXs, EC 1.11.1.9) and GSH sulfo-transferases (GSTs, EC 2.5.1.18) cumulatively form an efficient defense system to protect plants against ROS-induced effects in addition to their significance for the detoxification, chelation and compartmentalization of major TMs and metalloids in plants. The present review critically evaluates the recent studies on the modulation of total reduced GSH, GSH/GSSG redox couple, the major GSH-related enzymes and their cumulative significance in plants’ adaptation and/or tolerance to TMs and metalloids in detail.
Subfields: Environmental Chemistry, Nutrition and Dietetics, Plant Science
View Paper: https://www.semanticscholar.org/paper/7aa682d6dec180feb21e86539dbbed7e4287fd6e
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In Environmental Chemistry
In Nutrition and Dietetics
In Plant Science
- M. Fujita
- M. A. Hossain
- J. A. Teixeira da Silva
- F. J. Corpas
- D. Gupta
- J. Palma
- P. Piyatida
- M. Hasanuzzaman
Citations in the corpus
- Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “Thus, GSH and its redox couple are involved directly or indirectly in ROS metabolism (Anjum et al. 2012; Shi et al. 2015).”
- Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Glutathione in Detoxification of Reactive Oxygen Species and Methylglyoxal and in Heavy Metal Chelation (2012, background): “Likewise, the subcellular distribution of GSH and its related enzymes in model plant species may give deeper insight into compartment-specific HMs and metalloid-accrued reactions and resistance mechanisms and ROS and MG metabolism and other fundamental plant physiological process [13, 14].”