Autologous Bone Marrow–Derived Cultured Mesenchymal Stem Cells Delivered in a Fibrin Spray Accelerate Healing in Murine and Human Cutaneous Wounds

By V. Falanga, Satori Iwamoto, Molly Chartier, T. Yufit, J. Butmarc, N. Kouttab, D. Shrayer, P. Carson. Tissue engineering, 2007

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Fibrin: A Versatile Scaffold for Tissue Engineering Applications (2008, positive): “125,126,195 On the contrary, poor physical properties such as low mechanical strength and rapid degradation rates are the major disadvantages of ﬁbrin-based cell cultures.”
Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, positive): “The use of BM-MSCs in plastic surgery is less common and is mainly confined to wound therapy [181,182]; for example, a dose-dependent response was observed in patients with acute wounds from skin cancer surgery and chronic, long-standing nonhealing lower extremity wounds receiving cultured BM-derive”
Wound repair and regeneration: Mechanisms, signaling, and translation (2014, positive): “Along these lines, clinical studies have shown that bone marrow– and adipose tissue–derived MSCs can augment the repair process when applied locally to chronic skin wounds in patients (96, 150).”
Concise Review: Role of Mesenchymal Stem Cells in Wound Repair (2012, background): “…wound; 3 additional topical applications of cultured cells 3 Case studies All wounds healed with 3 applications or fewer Cultured adherent BM cells Falanga et al. 2007 55 Acute surgical Cultured and profiled BM-MSCs Topically suspended in fibrin spray 5 Case studies All acute wounds closed by 8…”