Cognitive Inflexibility After Prefrontal Serotonin Depletion

By Hannah F. Clarke, J. Dalley, Harriet S. Crofts, Trevor W. Robbins, A. C. Roberts. Science, 2004

626 citations recorded by the source corpus.

Subfields: Clinical Psychology, Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/7a4e015a73cb1841bb5dd4cd027728295b77bce3

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Citations in the corpus

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review (2010, background): “However, it will be important to resolve how these data fit with the consistent finding that 5-HT depletion in the OFC impairs visual object reversal learning in marmoset monkeys (Clarke et al, 2004, 2005; Yucel et al, 2007).”
The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation (2009, background): “This finding is theoretically significant because 5-HT depletion in the OFC produces robust and substantial deficits in reversal learning (Clarke et al. 2004, 2005, 2007).”
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective (2005, background): “Other excellent lines of research have attempted to differentiate the specific roles of dopaminergic, serotonergic, or noradrenergic systems in decision making, impulse contro”
Serotonin and brain function: a tale of two receptors (2017, background): “Serotonin depletion and inactivation has been shown to impair cognitive flexibility (Clarke et al., 2004, 2007; Matias et al., 2017) and there is evidence that this may be due to decreased basal activation of 5-HT2ARs (Boulougouris et al., 2008; Furr et al., 2012).”
Neuronal Reward and Decision Signals: From Theories to Data. (2015, background): “Serotonin has a similar tonic enabling function, which includes aversive and reward processes (100, 201, 481, 534, 635).”
Beta-adrenergic Modulation of Cognitive Flexibility during Stress (2007, background): “Many studies examining cognitive flexibility have examined the effect of the serotonergic (Evers et al., 2005; Clarke, Dailey, Crofts, Robbins, & Roberts, 2004 ) and dopaminergic (Floresco, Magyar, Ghods-Sharifi, Vexelman, & Tse, 2006) systems.”
Orbitofrontal cortex and its contribution to decision-making. (2007, background): “Later studies revealed that the deficit was specific to OFC (monkeys with lesions of lateral PFC were unimpaired) and depended on serotonergic innervation (Clarke et al. 2004, 2006; Dias et al. 1996).”
Neurophysiology of performance monitoring and adaptive behavior. (2014, background): “Selective neurotoxic lesions of the primate PFC with 5,7-dihydroxytryptamine (5,7-DHT) impaired reversal learning performance (90), an effect that could be reproduced by 5-HT (but not DA) depletions of the OFC (93).”
Modulators of decision making (2008, background): “Deficits in serotonin, especially in the medial prefrontal cortex, disturb adaptation to changes in the required action for a given cue (reversal learning) by making the subjects more likely to stick to prelearned behavior”
Bonsai Trees in Your Head: How the Pavlovian System Sculpts Goal-Directed Choices by Pruning Decision Trees (2012, background): “serotonin depletion impacts cognitive flexibility, or the adaptive ability to switch between contingencies, by impairing inhibitory control [37] in monkeys.”