Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.

By B. Giasson, J. Duda, I. Murray, Qiping Chen, José M. Souza, H. Hurtig, H. Ischiropoulos, John Q. Trojanowski, V. Lee. Science, 2000

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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics (2007, background): “Monoclonal antibodies that recognize only nitrated α-synuclein but not the unmodified protein or other tyrosine-nitrated proteins have also been generate”
Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System (2002, background): “A growing body of evidence has implicated -synuclein in the pathogenesis of Parkinson’s disease (PD) (Polymeropoulos et al., 1997; Kruger et al., 1998; Spillantini et al., 1998; Takeda et al., 1998; Giasson et al., 2000b ).”
Molecular pathophysiology of Parkinson's disease. (2005, background): “Oxidative damage may play a pertinent role in the aggregation of α-synuclein in sporadic PD because there is selective tyrosine nitration of α-synuclein in lesions in PD and other synucleinopathies (Giasson et al. 2000).”
DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation (2004, methodology): “Insulin aggregation was performed as described (Giasson et al. 2000).”
The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse (2001, background): “Both diseases are linked to increased oxidative damage, including NO-based damage to a specific protein, synuclein (Glasson et al., 2000).”