Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.

By L. Cirillo, F. Lin, Isabel Cuesta, D. Friedman, M. Jarnik, K. Zaret. Molecules and Cells, 2002

1,195 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/796c9221bcb5c311e3b033fa12066f68e64f0d24

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Citations in the corpus

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. (2007, background): “Previous studies have found that other GATA family members can open the compact chromatin through their conserved zinc finger motifs (Boyes et al., 1998; Cirillo et al., 2002).”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “Of the three, GATA4 may initiate the whole process by relaxing chromatin at key cardiogenic loci, thus facilitating access for the other factors acces”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “Since GATA proteins can bind to condensed chromatin and can induce local nuclease hypersensitivity, albeit more weakly than that by FoxA1 (Cirillo et al. 2002), GATA factors appear to function as pioneer factors for ER and AR in hormone-dependent cancers.”
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities (2010, background): “Several mechanisms have been proposed to explain this phenomenon, including protein-protein interactions that enable ternary complex formation with DNA (Verger and DuterqueCoquillaud, 2002),pioneering factors thatdisrupt the closednucleosome conformation and enable other factors to bind (Cirillo et ”
The evolution of Fox genes and their role in development and disease (2009, background): “The importance of this relatedness is shown by the binding of FoxA proteins, at least in vitro , to highly compacted chromatin, even in the absence of the SWI–SNF chromatin remodelling comple”
Epigenetic reprogramming and induced pluripotency (2009, background): “…to that of the transcription factors HNF3 (hepatocyte nuclear factor 3) and GATA4 (GATA binding protein 4), which bind to the albumin gene enhancer in silent chromatin and facilitate the opening of an H1-compacted nucleosome array on this enhancer to activate the gene (Cirillo et al., 2002).”
Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells (2014, background): “due to their ability to bind targets within closed chromatin (Cirillo et al. 2002; Lee et al. 2005; Friedman and Kaestner 2006).”