Rel/NF‐κB transcription factors: key mediators of B‐cell activation

By R. Gugasyan, R. Grumont, M. Grossmann, Yukio Nakamura, T. Pohl, D. Nesic, Steve. 2000

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Role of ζPKC in B‐cell signaling and function (2002, background): “Of potential interest, an essential role in B-cell maturation and survival has been reported for RelA and c-Rel (Gerondakis et al., 1999; Grossmann et al., 2000; Gugasyan et al., 2000).”
NF‐κB activation by protein kinase C isoforms and B‐cell function (2003, background): “This morphological phenotype, although less penetrant, generally weaker and restricted to young animals, is reminiscent of the alterations observed in several other NF-κB-pathway mutant mice (Gerondakis et al., 1999; Gugasyan et al., 2000).”
IKKβ Is Required for Peripheral B Cell Survival and Proliferation1 (2003, background): “As the function of NF- B subunits is perhaps best characterized in B cells (30, 31), we sought to investigate the role of IKK in B cell development and function.”