Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication

By Robinson Triboulet, B. Mari, Yea-Lih Lin, Christine Chable‐Bessia, Y. Bennasser, K. Lebrigand, B. Cardinaud, T. Maurin, P. Barbry, V. Baillat and 4 more. Science, 2007

665 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/790460c60172e3ade20632d4f49d005ab9d4cbb4

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In Cancer Research

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Citations in the corpus

• MicroRNAs in development and disease. (2011, background): “The inhibitory effects of HIV-1 miRNAs on viral production reconciles well with the suppressive effect that both Dicer and Drosha have on viral replication (620).”
• Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver (2007, neutral): “For example, a mutation in the target site of miR-189 in the human SLITRK1 gene was shown to be associated with Tourette’s syndrome (7), while other recent studies have implicated miRNAs in controlling HIV replication (8) and in coronary artery disease (9).”
• Biological functions of microRNAs: a review (2011, background): “The miRNA-silencing machinery plays a physiological role in controlling HIV-1 replication, inhibiting virus replication both in peripheral blood mononuclear cells from HIV-1-infected donors and in latently infected cells [ 61 ].”
• Antiviral immunity directed by small RNAs. (2007, neutral): “…virus (Lecellier et al., 2005; Otsuka et al., 2007), whereas a host factor critical to viral gene expression is suppressed in HIV-infected cells (Triboulet et al., 2007 )—both of which are required for human miRNA biogenesis/activity (Tolia and Joshua-Tor, 2007; Lee et al., 2006), whereas the…”
• Viruses, microRNAs, and Host Interactions (2010, background): “miR-17-5p and miR-20a target p300/CBP-associated factor (PCAF), a cellular histone acetylase and proposed cofactor of the HIV-1 Tat transactivator (92).”
• Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes (2007, background): “, and a recent report has indicated that cellular miR-17-5p and miR-20a have a role in regulating histone acetyltransferase Tat cofactor expression and HIV-1 replicatio”